LetsGetChecked vs myLAB Box: Which At-Home STD Kit Is Best?

LetsGetChecked and myLAB Box are both self-collect, mail-in STI kits with results in a few days, and both offer prescribed treatment on a positive. Choose LetsGetChecked for its own CLIA-certified labs and the largest pile of verified reviews. Choose myLAB Box for the widest 14-infection panel, built-in HIV screening, couples kits, and a free physician consult on a positive.

How each service works

Both companies follow the same basic mail-in model. You order online, a discreet box arrives, you collect your own sample at home, a finger-prick blood spot, a urine cup, or a swab depending on the infection, and you mail it back in a prepaid envelope. A lab processes the sample and posts your results to a secure online portal. Neither requires a clinic visit, and neither needs you to see a provider to get tested.

The meaningful difference is what happens to your sample at the lab and what happens after. LetsGetChecked runs its own CLIA-certified, CAP-accredited laboratories, meaning the same company that sells you the kit also controls the testing chain. myLAB Box partners with CLIA-certified labs to process its samples. CLIA certification is the federal standard that any lab reporting patient results in the US must meet FDA CLIA standards, so both clear that bar; LetsGetChecked simply owns more of the pipeline.

Test menu compared

This is where the two part ways most clearly. myLAB Box's flagship Total Box screens for 14 infections: the broadest single at-home panel you can buy, and the right pick for someone who wants one definitive sweep. It also includes HIV in its standard panels and offers HPV testing for women. LetsGetChecked has a quirk worth knowing before you buy: its Standard 5 and Complete 8 panels screen for Hepatitis B instead of HIV, with HIV sold as a separate add-on. If you assume a multi-test panel includes HIV by default, that gap can leave you with a false sense of being fully cleared.

Herpes coverage splits the two. myLAB Box tests HSV-2 only, the type behind most genital herpes. LetsGetChecked can cover both HSV-1 and HSV-2 (the oral and genital types), but only as a separate $119 add-on, it isn't bundled into any of its standard panels. If you specifically want both herpes types, budget for that add-on. If you're unsure which infections to screen for in the first place, work through which STD test do I need before you pick a panel, the panel name matters less than whether it covers the exposures you actually had.

Price and value

Both services are self-pay, and both accept HSA and FSA cards: neither bills insurance, so the sticker price is what you pay. myLAB Box single tests run $49: $99, with bundled panels and the Total Box costing more as the menu widens. LetsGetChecked prices by panel and offers subscription plans that lower the per-test cost for people who screen on a regular schedule. If you're paying out of pocket either way, it's worth comparing both against the clinic and pharmacy options in our guide to STD testing without insurance, sometimes a local program is cheaper than any mail-in kit. If neither brand fits your budget or panel needs, our roundup of the best at-home STD tests ranks the wider field.

Turnaround time

The lab speed is essentially a tie. Both return results in 2–5 days once your sample reaches the lab. The real variable is shipping, how fast you drop the sample in the mail and how long it travels, not the testing itself. Plan to collect and mail back the same day you open the box so the clock starts promptly.

Brand trust and lab quality

LetsGetChecked carries roughly 18,800 Trustpilot reviews at 4.4 out of 5, among the highest review volume of any at-home testing brand LetsGetChecked. Paired with its own CLIA-certified, CAP-accredited labs, that's the strongest argument for anyone who wants the most-vetted, quality-controlled option. CAP accreditation is a peer-inspection standard on top of CLIA, so the chain from kit to result is tightly controlled. myLAB Box uses CLIA-certified labs and ships in discreet, unbranded packaging, which matters if privacy at your mailbox or shared address is a concern. Both are legitimate; LetsGetChecked simply has the longer paper trail and tighter lab control. If you're weighing LetsGetChecked against another lab-owning brand, our STDcheck vs LetsGetChecked comparison covers that matchup too, and you can browse all STD testing services to see how either stacks up against the field.

One caveat that applies to every mail-in test: self-collected samples are only as good as the collection. If you'd like to understand where home tests can fall short, short of a clinic blood draw, the timing window for each infection, the chance of a false negative, read our breakdown of at-home test accuracy.

Couples testing and niche use cases

MyLAB Box offers couples kits, both partners collect and mail back together, which is genuinely useful for two people who want to test at the same time before starting or reopening a relationship. It's also the better fit if you want HPV screening or that single broad 14-infection sweep. LetsGetChecked leans toward the individual repeat tester: subscription plans suit someone screening on a regular cadence rather than a one-time check.

Support after a positive result

Both services build treatment into a positive result, so the difference is in who you talk to and what it costs. LetsGetChecked connects you with a nurse who can prescribe treatment in eligible states, billed as a $39 consult. myLAB Box includes a free physician telehealth consult on any positive, and that physician can prescribe for the common curable infections: chlamydia, gonorrhea, trichomoniasis, bacterial vaginosis, and more. So both let a positive lead directly to treatment without booking your own separate appointment; myLAB Box simply routes you to a physician at no extra charge, while LetsGetChecked uses a nurse and charges for the consult.

For curable bacterial infections like chlamydia and gonorrhea, that handoff speed matters: the sooner you treat, the sooner you stop transmission and lower your risk of complications. If you test positive with either service and want to confirm or move to treatment, you can also get tested and connect with care through us.

Who should choose LetsGetChecked

• You want the most-reviewed, own-lab option with CLIA and CAP accreditation behind it.
• You want a positive result to lead straight to a nurse-prescribed treatment without scheduling a doctor.
• You test on a regular schedule and want a subscription to lower the per-test cost.
• You specifically want both HSV-1 and HSV-2 covered (sold as a separate $119 add-on): and remember to add HIV too, since the standard panels screen Hep B instead.

Who should choose myLAB Box

• You want HIV included in your standard panel without a separate add-on.
• You want the single broadest sweep, the 14-infection Total Box.
• You and a partner want to test together with a couples kit.
• You want HPV testing (for women) or the most discreet, unbranded packaging.

Keep exploring on EasySTD: what STD testing costs and your risk of an STD.