Both myLAB Box and Wisp let you self-collect an STI sample at home and mail it to a lab, but they're built for different goals. myLAB Box is the breadth pick: its Total Box can screen up to 14 infections in a single kit, with couples and subscription options. Wisp is the convenience pick: it both tests and treats you, sending a same-day prescription to your pharmacy if a result for something like chlamydia or gonorrhea comes back positive. If you want the widest STD testing panel, lean myLAB Box; if you want care that doesn't end at the result, lean Wisp.
How each service works
With myLAB Box you order a kit online, it arrives in discreet unbranded packaging, you self-collect a finger-prick, urine or swab sample, mail it back with the prepaid label, and view secure results online. Every positive result includes a free physician phone consult. Samples are processed by CLIA-certified labs using the same assays as in-clinic tests myLAB Box test details, so accuracy is high when you test within the right window CLIA lab certification.
Wisp follows the same self-collect-and-mail model, routing samples to CLIA/CAP-accredited partner labs including LabCorp, Quest and Daye Wisp testing and labs. The difference comes after: a board-certified provider reviews your results, and a positive can trigger a same-day prescription to your local pharmacy (or discreet shipping). Wisp operates in all 50 states and also sells standalone $39 treatment consults and $22 DoxyPEP prevention.
Test menu compared
myLAB Box screens more infections overall: its Total Box adds Mycoplasma genitalium, 3-site chlamydia/gonorrhea and an HPV add-on. Wisp's menu is narrower but covers the essentials plus add-ons like herpes (HSV-1 and HSV-2), Mgen, Ureaplasma and 3-site testing, with treatment built in. The chart below compares features rather than ratings.
Head to head
| Test or feature | myLAB Box | Wisp |
|---|---|---|
| Widest panel | Up to 14 infections | Narrower, essentials plus add-ons |
| Collection | Finger-prick, urine or swab | Urine, finger-prick or swab |
| Turnaround | 2–5 days after lab | 3–5 days after lab |
| Treatment | Free consult on positive | Same-day Rx to pharmacy |
| Availability | Nationwide mail-in | All 50 states + treatment |
| Couples / subscription | Couples & subscription kits | Not offered |
| Prevention (DoxyPEP) | Not offered | DoxyPEP from $22 |
| Test or feature | myLAB Box | Wisp |
|---|---|---|
| Widest panel | Up to 14 infections (better) | Narrower, essentials plus add-ons |
| Collection | Finger-prick, urine or swab | Urine, finger-prick or swab |
| Turnaround | 2–5 days after lab (better) | 3–5 days after lab |
| Treatment | Free consult on positive | Same-day Rx to pharmacy (better) |
| Availability | Nationwide mail-in | All 50 states + treatment (better) |
| Couples / subscription | Couples & subscription kits (better) | Not offered |
| Prevention (DoxyPEP) | Not offered | DoxyPEP from $22 (better) |
Price and value
myLAB Box single tests run $49, $99 (HIV $49, chlamydia & gonorrhea $79), bundles scale from the Safe Box at $179 to the 14-infection Total Box at $379, $409, and the couples Love Box is $378 myLAB Box pricing. Wisp's 3-Panel Essential is $99, the 5-Panel is $179, and add-ons include HSV at $169 and Mgen at $125; a standalone treatment consult is $39 Wisp pricing. Both are self-pay with HSA/FSA accepted; neither bills insurance. Note Wisp's all-sales-final policy. Whether myLAB Box or Wisp is better value depends on whether you need breadth (myLAB Box) or bundled treatment (Wisp).
Privacy
Both services are HIPAA-compliant and ship in discreet, unbranded packaging. myLAB Box is self-pay only, which keeps testing private. Wisp is also HIPAA-compliant, but buyers should know it agreed in 2026 to settle a class action alleging it shared website activity with Meta through tracking pixels, a privacy issue common to many telehealth sites but worth weighing Wisp privacy notice. If maximum discretion is your priority, factor this in.
After a positive result
This is the clearest split. With myLAB Box, every positive includes a free physician phone consult to discuss next steps and where to seek treatment. With Wisp, a positive can be treated the same day, a provider sends a prescription to your local pharmacy or ships it discreetly. For curable infections like trichomoniasis, syphilis or NGU, that built-in treatment can save days. The CDC recommends prompt treatment after a positive result to prevent complications and onward transmission CDC STI screening guidance, and Wisp's model shortens that gap.
Who should choose myLAB Box
Pick myLAB Box if you want the widest at-home panel, up to 14 infections including HIV, hepatitis C and Mgen, or if you're testing as a couple or want a recurring subscription kit. It's also a strong fit if discretion matters most and you simply want a free physician consult to lean on if anything comes back positive.
Who should choose Wisp
Pick Wisp if you want testing and treatment from one provider, fast, especially same-day medication for a positive chlamydia or gonorrhea result. It's well-suited to anyone who wants prevention too (DoxyPEP from $22), a women's-health-focused telehealth experience, or nationwide coverage. Just weigh its newer testing track record and the 2026 Meta-pixel settlement. Compare more options on our best at-home STD test and reviews hubs.
Keep exploring on EasySTD: which STD test you need and what STD testing costs.