Minnehaha County reports about 13 new HIV diagnoses per 100,000 residents in Sioux Falls, South Dakota, near the US average. Whether you have symptoms or just want peace of mind, Sioux Falls, South Dakota offers both clinics where a provider can answer questions and start treatment, and at-home kits to collect a sample on your own schedule. You'll find options for both below.
Available testing centers
12 testing options are listed for Sioux Falls, SD. The nearest, Sanford Health Laboratories, is about 0.7 miles away. Compare community and public clinics, private labs, and at-home kits below.
Listings tagged Community health center are federally funded health centers and rural clinics that treat everyone regardless of insurance or ability to pay: required to bill on a sliding fee scale and provide confidential care, and in many states minors may consent to their own STI testing. A Title X tag flags centers funded for confidential family-planning services; confirm current participation when you call.
Source: CMS FQHC & Rural Health Clinic enrollment files (data.cms.gov), refreshed quarterly. Title X status reflects the latest OPA grantee list.
Sanford Health in Sioux Falls pairs rapid and conventional HIV testing, gonorrhea, chlamydia, syphilis, and herpes screening with same-visit treatment for bacterial infections. Appointments required. The full slate runs on a sliding-scale fee open to everyone, with donations accepted and insurance and Medicaid both taken, and every service carries no charge.
When cost stops someone from following through (skipping the follow-up, leaving treatment unstarted, sitting on a diagnosis) the gap between knowing and acting widens. At Sanford Health in Sioux Falls, no service carries a fee, so that gap doesn't open in the first place.
A missed detail during intake or a misunderstood treatment instruction can undo an otherwise complete visit. Sanford Health in Sioux Falls offers Spanish-language care and interpretation services for other languages, so the clinical exchange stays precise from the first question to the final instruction.
Many clinics cannot extend confidential family planning services to patients under 18: those visits surface on insurance, require a guardian, or simply fall outside the clinic's scope. As a Title X provider, Sanford Health in Sioux Falls delivers legally confidential family planning services to minors, with PrEP also available on-site.
Languages
English, Interpretation Services Available for Non-English Languages, Spanish
Tests offered
Serves
Care services
Prevention services
Fees & payment
Listing verified Apr 2026 · Source: CDC NPIN
Falls Community Health in Sioux Falls covers the full bacterial and viral panel (gonorrhea, chlamydia, syphilis, hepatitis A, B, and C, herpes, and rapid or conventional HIV) treats bacterial infections the same visit, and runs everything on a sliding scale, with all services available at no fee.
Sliding-scale clinics almost always land somewhere above zero, a reduced bill is still a bill. Falls Community Health charges nothing for any service it provides, so the sliding scale bottoms out completely rather than arriving at a copay.
Ryan White funding at Falls Community Health means a positive HIV result doesn't end the clinical relationship, it deepens it. The same site that runs the test manages ongoing HIV medical treatment, so care continues without transferring to a separate provider.
Falls Community Health prescribes both PrEP and PEP directly, with the lab monitoring, routine HIV and kidney-function testing, handled in-house on the same visit as a prescription review, keeping the clinical oversight continuous rather than scattered across providers.
Languages
English
Tests offered
Serves
Care services
Prevention services
Fees & payment
Listing verified Apr 2026 · Source: CDC NPIN + HRSA
South Dakota Urban Indian Health in Sioux Falls is a community-rooted health organization where STI care sits alongside TB, family planning, and chronic disease management: the full bacterial panel is treated same-visit, fees slide on income, and appointments are required. PrEP and PEP are both available on-site.
Many clinics test for HIV and hand off prevention to a separate prescriber. South Dakota Urban Indian Health writes PrEP prescriptions directly, keeping the conversation about ongoing prevention, and PEP when timing demands it, within the same clinical relationship rather than split across providers.
Hepatitis C treatment at South Dakota Urban Indian Health is an active clinical service, not a diagnostic endpoint. Prescribing and management happen in-house, which means the gap between a reactive antibody result and a completed treatment course doesn't require a separate specialist relationship.
The testing menu at South Dakota Urban Indian Health includes herpes and hepatitis A and B alongside gonorrhea, chlamydia, syphilis, and rapid HIV. A broader baseline that surfaces infections the four-pathogen standard panel leaves undetected and that carry distinct treatment or vaccination implications.
Languages
English
Tests offered
Serves
Care services
Prevention services
Fees & payment
Listing verified Jul 2025 · Source: CDC NPIN + HRSA
South Dakota Department of Health in Sioux Falls tests for HIV, syphilis, gonorrhea, chlamydia, hepatitis A, B, and C, and TB: all at no charge, including free hepatitis B and C testing specifically. Bacterial STIs are treated same visit; appointments are required.
Whether you're paying cash, uninsured, or simply without a regular provider, every test, vaccine, and treatment at South Dakota Department of Health in Sioux Falls carries no charge. TB treatment, DoxyPEP, HPV and hepatitis vaccines. The full scope runs on the same $0 basis.
Many public health clinics handle non-English speakers through external services that fragment the visit. South Dakota Department of Health in Sioux Falls provides interpretation directly, so counseling, test results, and prevention education happen in real time, with the same clinician, not routed through a separate channel.
DoxyPEP, doxycycline taken within 72 hours of potential bacterial STI exposure, is prescribed and managed at South Dakota Department of Health in Sioux Falls, not referred elsewhere. Clinicians handle the prescription, dosing guidance, and follow-up monitoring as part of the standard care workflow.
Languages
English, Interpretation Services Available for Non-English Languages
Tests offered
Serves
Care services
Prevention services
Fees & payment
Listing verified Feb 2026 · Source: CDC NPIN
Avera in Sioux Falls covers gonorrhea, chlamydia, syphilis, hepatitis B and C, and HIV testing with same-visit treatment for bacterial infections when needed; fees run on a sliding scale and insurance is accepted. Appointments are required. Prevention includes PrEP and PEP.
Avera writes PrEP prescriptions and manages PEP directly, so prevention and testing stay with the same clinical team. That continuity means medication adjustments, follow-up labs, and ongoing care happen in one place rather than across separate providers.
When hepatitis C goes untreated, the gap usually opens between a positive result and a specialist who can act on it. A gap that can stretch for months. At Avera in Sioux Falls, treatment is managed on-site, so a diagnosis doesn't sit idle waiting for a second appointment somewhere else.
Avera's panel extends beyond the standard four STIs to include hepatitis B and C testing, the standing capability that matters most for someone paying cash without a primary care physician who would otherwise order those labs. Sliding-scale fees apply to the full panel.
Languages
English
Tests offered
Care services
Prevention services
Fees & payment
Listing verified Apr 2026 · Source: CDC NPIN
Planned Parenthood North Central States in Sioux Falls tests for gonorrhea, chlamydia, syphilis, herpes, and HIV on a sliding-scale fee open to anyone, with insurance and Medicaid also accepted; bacterial infections treated same visit, by appointment.
Many clinics offer a number to dial and hand the phone across the desk, a setup that fragments the conversation and slows care. At Planned Parenthood North Central States in Sioux Falls, interpretation services are built into the visit itself, so the clinical exchange happens directly and completely, not through a patched-in relay.
Without Title X status, a minor seeking STI testing can find themselves navigating parental notification requirements that stop care before it starts. Planned Parenthood North Central States in Sioux Falls operates under Title X, which means family planning and STI services for minors are legally confidential. The protection is statutory, not a clinic policy that can shift.
PrEP isn't a single prescription: it requires regular HIV testing, kidney function monitoring, and prescription renewals to stay effective. Planned Parenthood North Central States in Sioux Falls manages that full cycle in-house, and also prescribes PEP for post-exposure prevention, with clinical staff who handle both the initiation and the follow-through.
Languages
English, Interpretation Services Available for Non-English Languages
Tests offered
Serves
Care services
Prevention services
Fees & payment
Listing verified Aug 2025 · Source: CDC NPIN
A safety-net rural health clinic about 15 miles from Sioux Falls. Sliding-scale STD testing and care are typical here, call ahead to confirm the exact panel and pricing.
Tests offered
A community safety-net rural health clinic about 23 miles from Sioux Falls. Sliding-scale STD testing and care are typical here, call ahead to confirm the exact panel and pricing.
Tests offered
Free tool · not a clinic
Testing too soon can miss an infection. Enter the date of possible exposure to see the earliest a test can reliably detect each STI.
| Infection | Earliest reliable test | Conclusive after |
|---|---|---|
| Chlamydia | 7 days after exposure | 14 days after exposure |
| Gonorrhea | 7 days after exposure | 14 days after exposure |
| Trichomoniasis | 7 days after exposure | 28 days after exposure |
| HIV (NAT / RNA) | 10 days after exposure | 33 days after exposure |
| HIV (4th-gen Ag/Ab) | 18 days after exposure | 45 days after exposure |
| HIV (antibody) | 21 days after exposure | 84 days after exposure |
| Syphilis | 21 days after exposure | 42 days after exposure |
| Hepatitis B | 21 days after exposure | 42 days after exposure |
| Hepatitis C | 56 days after exposure | 77 days after exposure |
| Herpes (HSV) | 28 days after exposure | 112 days after exposure |
Guidance only, confirm timing with a clinician. A negative result before the conclusive date may need a repeat test.
Typical out-of-pocket ranges by option, actual cost depends on which tests you need.
Public / community clinic
Free HIV testing is common
Private lab (self-pay)
Never billed to insurance
At-home kit
Mailed to your door, private
Doctor / urgent care
Often $0 preventive with insurance
No centers match those filters. Clear the service-type filter or the opening-hours filters to see every center.
Every other option
Beyond the dedicated testing centers above: at-home kits by mail, hospital labs certified for STI testing, local clinicians who can order a panel during a regular visit, pharmacies for self-test kits and prescriptions, and online PrEP & treatment.
Test from home
The nearest testing center is less than a mile away; if you'd rather skip the trip, an at-home kit ships to Sioux Falls, you collect the sample privately, and mail it back to a CLIA-certified lab. Results come online in days, with a clinician available if anything is positive. Same labs as a clinic, no waiting room, and you can read how accurate at-home STD tests are before you order.
Want a free option first? The CDC-supported TakeMeHome (opens in a new tab) program mails free at-home HIV self-test kits, and, in many areas, free STI kits, to your door, with no insurance or payment needed. The paid kits below add broader panels and faster turnaround.
In-home collection
$79 & up
Best range: couples & full panels
$79 & up
Best value: single tests
$49 & up
Every kit uses CLIA-certified labs. At-home testing is for screening; a reactive result should be confirmed and treated by a clinician. Prices and panels shown are illustrative and change often, confirm current details on the provider's site.
Also in the area
Beyond the public testing sites above, these federally certified (CLIA) labs serve Minnehaha County, each lab's town is shown on its card below. Many test through a doctor's order or by appointment rather than walk-in, so call ahead to confirm STD/STI testing and availability before visiting.
3401 West 49th, Sioux Falls, SD 57106
CMS-certified lab Accredited · Joint Commission
4405 East 26th Street, Sioux Falls, SD 57103
CMS-certified lab Accredited · Joint Commission
6110 South Minnesota Avenue, Sioux Falls, SD 57108
CMS-certified lab Accredited · Joint Commission
6101 South Louise Avenue, Sioux Falls, SD 57108
CMS-certified lab Accredited · Joint Commission
600 North Sycamore Avenue, Sioux Falls, SD 57103
CMS-certified lab Accredited · Joint Commission
Showing the nearest 5 CLIA-certified labs.
Source: CMS CLIA registry (Provider of Services), Q1 2026. Federal public records: active CLIA-certified laboratories near Sioux Falls. A CLIA certificate records only that a laboratory is federally certified — it does not confirm the site performs STD testing, nor its hours, price or access. Inclusion is not an endorsement; always call to verify.
Local clinicians
Beyond dedicated clinics, 302 primary-care, OB-GYN, infectious-disease and other clinicians have a CMS practice record within 30 miles of Sioux Falls. They may be able to evaluate symptoms or order a confidential STD panel during a regular visit, and 39 offer telehealth.
Darcey Stockland, MD
Family medicine · Sanford Clinic Provider Enrollment, Sioux Falls
Syed Asif Shah, MD
Internal medicine · 6709 South Minnesota Avenue, Sioux Falls
Bradley Hruby, MD Telehealth
Family medicine · 7600 South Minnesota Avenue, Sioux Falls
Brian Tjarks, MD
Family medicine · 4000 North Brendan Lane, Sioux Falls
Mark Anthony Diaz, MD Telehealth
Infectious disease · 6709 South Minnesota Avenue, Sioux Falls
Andrea Seurer, MD
Family medicine · 1001 East 21st Street, Sioux Falls
These are registry-listed clinicians, not dedicated STD-testing clinics. CMS records do not independently verify current licensure, testing services, availability, price, or new-patient status. Confirm each detail before booking. Source: CMS Doctors & Clinicians.
Nearby pharmacies
No pharmacy near Sioux Falls, SD publishes an STD-related service or holds a current CLIA testing certificate, so these are simply the closest. Contact a location directly to confirm counter hours, services, prices, and availability before visiting.
Lewis Drug
0.6 miLewis Family Pharmacy
0.7 mi
0.7 mi Avera 7th Avenue Pharmacy
0.8 miVanhove Prescription Shop
0.8 miAvera McKennan Pharmacy
1.0 miShowing the 6 closest pharmacies to Sioux Falls, SD.
Directory records identify nearby pharmacies. Service, stock, price, and hours information is shown only when supported by current location-specific evidence.
Prevention & treatment
Testing is one step. For residents of Sioux Falls, telehealth covers the rest: HIV-prevention medication (PrEP) and DoxyPEP to lower future risk, and discreet online treatment if a result comes back positive. All prescribed by licensed U.S. clinicians.
$0 with most insurance
Free online PrEP & DoxyPEP: HIV prevention, home lab kits, no in-person visit
From $0 insured
Telehealth PrEP & DoxyPEP with at-home testing and ongoing monitoring
Visit from $0 insured
Telehealth STI treatment and sexual-health care, delivered or to your pharmacy
Visit from $39
Online STI treatment & DoxyPEP: same-day prescriptions to your pharmacy
Pricing varies by insurance and changes often, confirm on the provider's site. These services are not a substitute for emergency care.
STD stats & rates
How reported STI rates in Minnehaha County, the county that includes Sioux Falls, compare with South Dakota and U.S. averages, based on the most recent 2023 surveillance data. An estimated ~29% of residents are aged 15–34 (ACS), the age group with the highest reported chlamydia and gonorrhea rates nationally.
#11 of 66 South Dakota counties for chlamydia, a higher rate than 83% of the state
| Infection | Minnehaha County | South Dakota | United States |
|---|---|---|---|
| Chlamydia | 698.8 1,446 cases ▲ 31% | 531.6 | 492.2 |
| Gonorrhea | 365.3 756 cases ▲ 44% | 253.3 | 179.5 |
| Syphilis (P&S) | 56.5 117 cases ▼ 23% | 73.4 | 15.8 |
| Syphilis (early) | 50.7 105 cases ▼ 34% | 76.8 | 16 |
| Syphilis (late/unknown) | 51.2 106 cases ▼ 30% | 72.9 | 29.5 |
Rates per 100,000 population, 2023. Source: CDC NCHHSTP AtlasPlus (county, state & U.S., all-ages basis). Population figures: U.S. Census Bureau ACS. These figures are the latest available surveillance estimates. Bars are scaled to the highest rate shown.
Reading these numbers: reported case rates only count infections that were actually tested for and diagnosed, so they track local screening effort as much as true spread: a higher rate can reflect more testing, a lower one less. Either way, most STIs cause no symptoms, so treat the figures above as context rather than a verdict, and test on the CDC's schedule regardless of how your area looks.
Between 2020 and 2023 in Minnehaha County, chlamydia has risen from 565.9 to 698.8 per 100,000 (23%), gonorrhea has fallen from 412.2 to 365.3 per 100,000 (11%), and P&S syphilis has risen from 8.6 to 56.5 per 100,000 (557%).
The 2020 dip reflects reduced pandemic-era screening, not lower transmission. Source: CDC NCHHSTP AtlasPlus (county, state & U.S., all-ages basis).
Community health context
Sources: CDC PLACES (ZIP), County Health Rankings, CDC/ATSDR SVI, HRSA HPSA, HRSA MUA/P, Neighborhood Atlas ADI. Lower insurance coverage, fewer routine checkups, and a thin primary-care ratio all raise the value of low-cost public clinics and at-home testing in Minnehaha County.
Local HIV snapshot
Minnehaha County HIV care continuum (2023)
Minnehaha County recorded 13 new HIV diagnoses per 100,000 (2023), against 6.8 statewide and 13.7 nationally. Among Minnehaha County residents living with HIV, 90.8% are in care · 54.8% are virally suppressed. Early, routine testing is what moves these numbers: it is the entry point to PrEP, treatment, and viral suppression.
Sources: AIDSVu (Emory/Gilead) · CDC AHEAD · CDC AtlasPlus · CDC NCHHSTP AtlasPlus (county care continuum). The CDC recommends everyone aged 13–64 test for HIV at least once: every lab and clinic listed above offers HIV testing, and free rapid HIV testing is available at a local health department.
Congenital syphilis, passed from parent to baby in pregnancy, is the fastest-rising STI in the country. U.S. cases climbed from 2,163 in 2020 to 3,882 in 2023. It is almost entirely preventable: the CDC recommends a syphilis test at the first prenatal visit, and every clinic and lab listed for Minnehaha County tests for syphilis.
Source: CDC NCHHSTP AtlasPlus, 2023 (county-level congenital syphilis is not published).
Local resources & officials
Data & references
Local context
Along South Minnesota Avenue, where households averaging three people navigate health decisions together, a positive test, a delayed appointment, or an avoided conversation ripples through the whole home. That dynamic shapes how sexual health fits into daily life here, whether a couple shares a primary-care provider or one partner quietly handles things alone. The city's workforce participation is remarkably high, meaning most adults are clocking real hours, and for younger residents in their late teens and twenties, already navigating entry-level wages against rents that can consume a meaningful slice of a paycheck, booking a clinic visit mid-week isn't always simple arithmetic.
That geographic spread matters because people in their twenties and early thirties represent the years when STIs circulate most actively, and access that's close to where someone already lives or works makes follow-through far more likely. Minnehaha County's STI rates give the broader picture context; what these clinic listings add is specificity (an address, a fee, a Saturday hour) that turns an intention formed somewhere near the Washington Pavilion into an actual appointment kept.
Getting there
Sioux Falls scores 10.8/20 on the EPA walkability index, so many trips are walkable or a short ride, though a car still gives you the widest choice of testing centers.
Source: EPA National Walkability Index 2021.
Sioux Falls sits in Minnehaha County. Local context that shapes where residents test:
Local landmarks
Neighborhoods & communities
Major routes
Nearby cities & towns
Just outside Sioux Falls? These nearby communities have their own testing guides: clinics, at-home kits, and free screening close to home.
Reference
Everything to know before you test in Minnehaha County: the CDC's screening guidelines, each infection's detection window, per-test reference prices, and your privacy rights under South Dakota law. If you have symptoms right now, our confidential symptom checker maps them to the tests worth considering.
Based on current CDC screening recommendations.
| Group | Tests | How often |
|---|---|---|
| Everyone aged 13–64 | HIV | At least once |
| Sexually active women under 25 | Chlamydia, gonorrhea | Every year |
| Women 25+ with new or multiple partners | Chlamydia, gonorrhea | Every year |
| Pregnant people | HIV, syphilis, hepatitis B & C, chlamydia | Early in pregnancy |
| Gay & bisexual men (MSM) | Chlamydia, gonorrhea, syphilis, HIV | Every 3–6 months |
| Anyone who shares injection equipment | HIV, hepatitis B & C | At least yearly |
| All adults at least once | Hepatitis C | At least once |
Testing too early can return a false negative, confirm timing with a Sioux Falls-area provider.
| Infection | Earliest reliable test | Sample |
|---|---|---|
| Chlamydia | 1–2 weeks | Urine or swab |
| Gonorrhea | 1–2 weeks | Urine or swab |
| Trichomoniasis | 1–4 weeks | Urine or swab |
| HIV (NAT / RNA) | 10–33 days | Blood |
| HIV (4th-gen Ag/Ab) | 18–45 days | Blood |
| HIV (antibody) | 3–12 weeks | Blood / oral |
| Syphilis | 3–6 weeks | Blood |
| Hepatitis B | 3–6 weeks | Blood |
| Hepatitis C | 8–11 weeks | Blood |
| Herpes (HSV) | 4–16 weeks (antibody); swab a sore | Blood / swab |
These are the federal Medicare reference prices for processing each lab test. Public clinics and the community health centers serving Sioux Falls often test free or on a sliding scale; private labs and at-home kits bundle several tests into one fee. Use this as a per-test benchmark before you pay out of pocket, or see the full guide to STD test costs for insurance, free, and at-home options.
| Test | Reference price | CPT / HCPCS |
|---|---|---|
| Chlamydia (NAAT) | $47.80 | 87491 |
| Gonorrhea (NAAT) | $47.80 | 87591 |
| Trichomoniasis (NAAT) | $47.76 | 87661 |
| HIV-1/2 antigen/antibody | $26.87 | 87389 |
| HIV-1/2 antibody | $22.44 | 86703 |
| Syphilis (RPR/VDRL) | $5.61 | 86592 |
| Syphilis (treponemal antibody) | $17.49 | 86780 |
| Herpes (HSV NAAT) | $47.76 | 87529 |
| Hepatitis B surface antigen | $15.33 | 87340 |
| Hepatitis C antibody | $29.16 | 86803 |
Source: Medicare Clinical Laboratory Fee Schedule, CMS, 2025 rates (data.cms.gov). Reference rate for the lab assay only: a clinic visit, sample collection, or a bundled multi-test panel may cost more. Medicaid and most insurers cover STD screening at no out-of-pocket cost.
Two things that actually depend on South Dakota law: who can consent, and whether partners can be treated without their own visit. Everything else about testing privately is the same nationwide (see below).
In South Dakota, a minor of any age can consent to confidential STI testing and treatment on their own, no parental permission is required.
Expedited Partner Therapy (EPT) is potentially allowable in South Dakota: it is not expressly authorized, but not prohibited either. Ask your provider whether they will prescribe treatment for a partner without a separate visit.
Keeping a test private works the same in every state. Whether an STD test shows on insurance (the EOB), how to test anonymously, and self-pay options that leave no insurance trail don’t change by location.
Learn more about confidential STD testing in South DakotaSource: Guttmacher Institute, Minors' Access to STI Services; CDC, Legal Status of Expedited Partner Therapy. General information, not legal advice.
Good to Know
Answers to the questions people ask most before getting tested.
The closest is Sanford Health Laboratories (0.7 mi); 12 options are within 30 miles.
Medicaid generally covers STD testing, and public clinics test for free regardless of coverage.
Yes, Falls Community Health (0.9 mi) offers free testing, and public clinics serve the uninsured.
Local options test for Chlamydia, Gonorrhea, Syphilis, Herpes, Hepatitis A, Hepatitis B, Hepatitis C, Rapid HIV, a full panel covers the common ones.
About 699 cases per 100,000 residents (2023), above the South Dakota average.
In South Dakota, people under 18 can consent to confidential STD testing and treatment on their own.
PrEP (HIV-prevention medicine for HIV-negative people) is available locally, any provider can prescribe it.
Yes, from a reputable lab, confirm any positive with a clinician for treatment.
Yes, most chlamydia infections cause no symptoms, so screening is the only reliable way to catch it.
The gap between exposure and when a test can reliably detect the infection; testing inside it can miss a real infection.
Have a different question? Browse the full STD & STI FAQ library, every question we answer, in one place.